You want to use a database of information about tissue samples to classify future tissue...

There are very few occurrences of mutations relative to normal samples.

There are roughly equal occurrences of both normal and mutated samples in the database.

You expect future mutations to have different features from the mutated samples in the database.

You expect future mutations to have similar features to the mutated samples in the database.

You already have labels for which samples are mutated and which are normal in the database.