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A 67-year-old man presents to the clinic because of elevated liver enzymes.

A 67-year-old man presents to the clinic because of elevated liver enzymes. He is asymptomatic.His medical history is significant for type 2 diabetes, which is being treated with metformin. On physical examination, he looks well. His blood pressure is 125/75 mm Hg, his heart rate is 80/min, and his BMI is 35. Findings of the remainder of the examination are normal. His blood work results are as follows:

    Platelet count: 170 × 10⁹/L (130–380)

    Creatinine: normal

    GGT: 75 µmol/L (49–93)

    ALT: 146 IU/L (15–85)

    AST: 101 IU/L (17–63)

    Bilirubin (total): 17 µmol/L (3–17)

    INR: 1.2 (0.9–1.2)

Which one of the following is the most likely diagnosis?

A.

Acute hepatitis B infection

B.

Carcinoma of the pancreas

C.

Nonalcoholic steatohepatitis

D.

Metformin effect

E.

Hepatocellular carcinoma

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