What is a normal response to dobutamine stress testing?

During dobutamine stress testing, a normal physiological response includes increased myocardial contractility leading to a decrease in left ventricular (LV) cavity size during systole due to more effective ejection. Concurrently, systolic blood pressure increases due to the inotropic and chronotropic effects of dobutamine.

An increase in LV cavity size during stress would suggest impaired contractility or ischemia, which is abnormal.

This normal response is detailed in the "Textbook of Clinical Echocardiography, 6e", Chapter on Stress Echocardiography and Hemodynamic Responses【20:400-405†Textbook of Clinical Echocardiography】.