Which of the following medication combinations should be avoided due to the increased potential forliver...

Percocet (oxycodone/acetaminophen) and Tylenol (acetaminophen)should be avoided together becauseboth contain acetaminophen.

High doses of acetaminophen (>4,000 mg/day in adults)can causesevere liver toxicity, leading to acute liver failure.

Acetaminophen is metabolized by theliver enzyme CYP2E1, producingtoxic metabolitesthat, in excess, overwhelm the liver’s ability to detoxify them.

Why Other Options Are Incorrect:

Motrin (ibuprofen) + Ativan (lorazepam):No liver toxicity risk.✅

Motrin (ibuprofen) + Tylenol (acetaminophen):Not inherently dangerous but can causeGI bleedingandkidney damagewith long-term use.

Percocet (oxycodone/acetaminophen) + Ativan (lorazepam):Risk ofCNS depression, butnotliver toxicity.

????Reference:FDA Acetaminophen Safety Guidelines,CDC Liver Toxicity Warnings.