Medication bound to protein can have which of the following effects?

Only an unbound drug can be distributed to active receptor sites. Therefore, the more of a drug that is bound

to protein, the less it is available for the desired drug effect. Choice 1 is incorrect because less drug is available if

it is bound to protein. Choice 2 is incorrect because distribution to receptor sites is irrelevant if the drug, which is

bound to protein, cannot bind with a receptor site. Choice 4 is incorrect because metabolism is not increased. The

liver first has to remove the drug from the protein molecule before metabolism can occur. The protein is then free

to return to circulation and be used again.Pharmacological Therapies