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A 67-year-old man underwent his first endoscopy.

A 67-year-old man underwent his first endoscopy. He has long-term reflux and heartburn, treatedintermittently with antacids. Biopsies of the distal esophagus reveal Barrett epithelium. Which one of the following is most important in determining the frequency of surveillance endoscopy?

A.

Length of Barrett segment

B.

Depth of intestinal metaplasia

C.

Stricture formation

D.

Grade of dysplasia

E.

Family history of gastrointestinal malignancy

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