A 38-year-old woman presents with diffuse nodularity in the outer upper quadrant of her right...

Fibrocystic change is the most common benign breast condition in women of reproductive age. It typically presents with diffuse nodularity or "lumpy" areas, especially in the upper outer quadrant, and varies with the menstrual cycle. No dominant mass or systemic signs are expected.

Toronto Notes 2023 – Gynecology, “Benign Breast Conditions”:

“Fibrocystic changes often present with bilateral or unilateral nodularity, most commonly in the upper outer quadrants, without discrete masses.”

MCCQE1 Objectives (Gynecology > 81-1: Breast Conditions):

“Candidates must differentiate benign breast conditions from malignant ones based on presentation and physical exam findings.”

Paget disease (B) presents with nipple changes. Intraductal carcinoma (C) typically shows a discrete mass or suspicious features. Phyllodes tumours are usually well-circumscribed. Mastitis (E) is inflammatory and associated with erythema, fever, and tenderness.