A 22-year-old woman is brought to the Emergency Department by her boyfriend, who says that...

For pregnant patients with opioid use disorder, opioid agonist therapy with methadone or buprenorphine is the standard of care. Detoxification is not recommended in pregnancy due to increased risk of fetal distress, preterm labor, and relapse. Methadone reduces illicit opioid use and stabilizes both mother and fetus.

Toronto Notes 2023 – Addiction Medicine / Obstetrics:

“Methadone maintenance therapy is the treatment of choice for pregnant patients with opioid use disorder. Detoxification is not advised during pregnancy due to relapse risk and potential harm to the fetus.”

MCCQE1 Objectives (Obstetrics > 80-3: Substance Use in Pregnancy):

“Candidates must manage opioid use disorder in pregnancy with evidence-based therapies, including referral for methadone or buprenorphine.”

Counselling alone (D) is insufficient as first-line therapy. Home detox (C) is unsafe. Inpatient detox (A) is not recommended in pregnancy.

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