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All of the following statements concerning the lyophilization of a parenteral product are correct, EXCEPT:

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All of the following statements concerning the lyophilization of a parenteral product are correct, EXCEPT:

A.

There is minimal loss of activity in heat labile materials.

B.

The liquid must be frozen to below the eutectic temperature.

C.

The solute usually forms an amorphous glass.

D.

The eutectic temperature is the freezing point of the drug solution.

E.

Water is removed from the frozen mixture by sublimation.

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