The most common finding in a patient who is experiencing a sickle cell crisis is

Comprehensive and Detailed Explanation From Exact Extract:

Sickle cell crisis (vaso-occlusive crisis) occurs when abnormally shaped red blood cells obstruct blood flow, leading to:

Severe localized or generalized pain (most common symptom)

Often in the back, chest, abdomen, or long bones

Hypoxia may be a contributing factor, but pain is the most reported reason for EMS activation. Cardiac arrhythmias and hypertension are not primary symptoms of sickle cell crisis.