The most effective method to mitigate future infections caused by connecting a Universal Serial Bus (USB) storage device is to implement centralized technical control of USB port connections. USB port connections are the physical interfaces that allow USB devices, such as flash drives, keyboards, or mice, to connect to a computer or a network. USB port connections can pose a security risk, as they can be used to introduce or spread malware, to steal or leak data, or to bypass other security controls. Centralized technical control of USB port connections is a technique that uses a centralized system or a policy to monitor, restrict, or disable the USB port connections on the computers or the network. Centralized technical control of USB port connections can prevent or limit future infections caused by connecting a USB storage device, as it can block or allow the USB devices based on various criteria, such as the device type, the device ID, the user ID, the time, or the location. Centralized technical control of USB port connections can also provide some benefits for web security, such as enhancing the visibility and the auditability of the USB activities, enforcing the compliance and the consistency of the USB policies, and reducing the reliance and the burden on the end users. Develop a written organizational policy prohibiting unauthorized USB devices, train users on the dangers of transferring data in USB devices, and encrypt removable USB devices containing data at rest are not the most effective methods to mitigate future infections caused by connecting a USB storage device, although they may be related or useful techniques. Develop a written organizational policy prohibiting unauthorized USB devices is a technique that uses a formal document to define and communicate the rules and the expectations regarding the usage of USB devices on the computers or the network. Develop a written organizational policy prohibiting unauthorized USB devices can provide some benefits for web security, such as raising the awareness and the responsibility of the parties, establishing the standards and the guidelines for the USB activities, and providing the basis and the justification for the enforcement and the sanctions of the USB policies. However, develop a written organizational policy prohibiting unauthorized USB devices is not sufficient to prevent or limit future infections caused by connecting a USB storage device, as the policy may not be effectively implemented, communicated, or followed by the parties, and it may not be able to address the dynamic and the complex nature of the USB threats. Train users on the dangers of transferring data in USB devices is a technique that uses education and awareness programs to inform and instruct the users about the risks and the best practices of using USB devices on the computers or the network. Train users on the dangers of transferring data in USB devices can provide some benefits for web security, such as improving the knowledge and the skills of the users, changing the attitudes and the behaviors of the users, and empowering the users to make informed and secure decisions regarding the USB activities.