A material had been oxidized many times, without incident, under an oxygen atmosphere in a...

The correct answers are B (Management of Change) and D (Process Knowledge Management) because this incident was caused by unrecognized hazards introduced during scale-up and process modification .

Option B (Management of Change - MOC) is critical because the engineers introduced a new feed dispersing system , which significantly altered the process by creating a combustible mist in the vapor space . According to CCPS, any change in equipment, process conditions, or technology must undergo a formal MOC review to identify new hazards, evaluate risks, and implement safeguards before startup. A proper MOC would likely have identified the explosion risk associated with mist formation in an oxygen-rich environment.

Option D (Process Knowledge Management - PKM) is also essential because the hazard resulted from insufficient understanding of the process chemistry and physical behavior , particularly mist explosibility and catalyst ignition potential. PKM ensures that organizations maintain accurate knowledge of chemical reactivity, flammability limits, and scale-up effects.

Options A , C , and E are not directly related to preventing this type of incident. Measurement and metrics track performance, contractor management is irrelevant here, and emergency management focuses on response rather than prevention.

This scenario highlights how scale-up changes can introduce new hazards , requiring both strong MOC and robust process knowledge.